Gonadotropin

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Glycoprotein hormone
Identifiers
Symbol Hormone_6
Pfam PF00236
InterPro IPR000476
PROSITE PDOC00623
SCOP 1hcn
SUPERFAMILY 1hcn
OPM protein 1fl7

Gonadotropins (or glycoprotein hormones) are protein hormones secreted by gonadotrope cells of the anterior pituitary of vertebrates.[1][2][3] This is a family of proteins, which include the mammalian hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), placental chorionic gonadotropins hCG and eCG[4] and chorionic gonadotropin (CG), as well as at least two forms of fish gonadotropins. These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function.[5] The hormones LH and FSH are secreted by the anterior pituitary gland, while hCG and eCG are secreted by the placenta.[6]

Gonadotropin is sometimes abbreviated Gn. The British spelling is gonadotrophin.

Natural types and subunit structure[edit]

The two principal gonadotropins in vertebrates are luteinizing hormone (LH) and follicle-stimulating hormone (FSH), although primates produce a third gonadotropin called chorionic gonadotropin (CG). LH and FSH are heterodimers consisting of two peptide chains, an alpha chain and a beta chain. LH and FSH share nearly identical alpha chains (about 100 amino acids long), whereas the beta chain provides specificity for receptor interactions. These subunits are heavily modified by glycosylation.

The alpha subunit is common to each protein dimer (well conserved within species, but differing between them[5]), and a unique beta subunit, which confers biological specificity.[4] The alpha chains are highly conserved proteins of about 100 amino acid residues which contain ten conserved cysteines all involved in disulfide bonds,[7] as shown in the following schematic representation.

                       +---------------------------+
           +----------+|             +-------------|--+
           |          ||             |             |  |
       xxxxCxCxxxxxxCxCCxxxxxxxxxxxxxCCxxxxxxxxxxCxCxxCx
             |      |                 |          |
             +------|-----------------+          |
                    |                            |
                    +----------------------------+

'C': conserved cysteine involved in a disulphide bond.

Intracellular levels of free alpha subunits are greater than those of the mature glycoprotein, implying that hormone assembly is limited by the appearance of the specific beta subunits, and hence that synthesis of alpha and beta is independently regulated.[4]

Another human gonadotropin is human chorionic gonadotropin (hCG), produced by the placenta during pregnancy.

Mechanism[edit]

Gonadotropin receptors are embedded in the surface of the target cell membranes and coupled to the G-protein system. Signals triggered by binding to the receptor are relayed within the cells by the cyclic AMP second messenger system.

Gonadotropins are released under the control of gonadotropin-releasing hormone (GnRH) from the arcuate nucleus and preoptic area of the hypothalamus. The gonadstestes and ovaries — are the primary target organs for LH and FSH. The gonadotropins affect multiple cell types and elicit multiple responses from the target organs. As a simplified generalization, LH stimulates the Leydig cells of the testes and the theca cells of the ovaries to produce testosterone (and indirectly estradiol), whereas FSH stimulates the spermatogenic tissue of the testes and the granulosa cells of ovarian follicles.

Diseases[edit]

Gonadotropin deficiency due to pituitary disease results in hypogonadism, which can lead to infertility. Treatment includes administered gonadotropins, which, therefore, work as fertility medication. Such can either be produced by extraction and purification from urine or be produced by recombinant DNA.

Failure or loss of the gonads usually results in elevated levels of LH and FSH in the blood.

Pharmacologic preparations[edit]

There are various preparations of gonadotropins for therapeutic use, mainly as fertility medication. For example, the so-called menotropins (also called human menopausal gonadotropins) consist of LH and FSH extracted from human urine from menopausal women.[8] There are also recombinant variants.

References[edit]

  1. ^ Parhar, Ishwar S. (2002). Gonadotropin-releasing Hormone: Molecules and Receptors. Amsterdam: Elsevier. ISBN 0-444-50979-8. 
  2. ^ Pierce JG, Parsons TF (1981). "Glycoprotein hormones: structure and function". Annu. Rev. Biochem. 50: 465–495. doi:10.1146/annurev.bi.50.070181.002341. PMID 6267989. 
  3. ^ Stockell Hartree A, Renwick AG (1992). "Molecular structures of glycoprotein hormones and functions of their carbohydrate components". Biochem. J. 287 (Pt 3): 665–679. PMC 1133060. PMID 1445230. 
  4. ^ a b c Goodwin RG, Moncman CL, Rottman FM, Nilson JH (1983). "Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones". Nucleic Acids Res. 11 (19): 6873–6882. doi:10.1093/nar/11.19.6873. PMC 326420. PMID 6314263. 
  5. ^ a b Godine JE, Chin WW, Habener JF (1982). "alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs". J. Biol. Chem. 257 (14): 8368–8371. PMID 6177696. 
  6. ^ Golos TG, Durning M, Fisher JM (1991). "Molecular cloning of the rhesus glycoprotein hormone alpha-subunit gene". DNA Cell Biol. 10 (5): 367–380. doi:10.1089/dna.1991.10.367. PMID 1713773. 
  7. ^ Isaacs NW, Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ (1994). "Crystal structure of human chorionic gonadotropin". Nature 369 (6480): 455–461. doi:10.1038/369455a0. PMID 8202136. 
  8. ^ Menotropins at the US National Library of Medicine Medical Subject Headings (MeSH)

External links[edit]