George Dyke is a mobster who was executed in a gas chamber at Gotham City Prison on a rainy evening. However, his brain is removed from his body by his henchman under his orders. George's brain ends up transplanted into the body of a towering gorilla by a disgraced surgeon named Doc Willard. The Gorilla Boss establishes a crime spree in Gotham and fights Batman twice.
Sinestro later steals Gorilla Boss' cerebellum, expands it to planet-size, and used it as a power source. This unnatural abomination is destroyed by Superman.
Gorilla Boss's brain is later returned to his gorilla body. He then gets used as a pawn by Gorilla Grodd.
Gorilla Boss appears in the Batman: The Brave and the Bold episode "Gorillas in our Midst!" voiced by Diedrich Bader. This incarnation of him is capable of human speech. He alongside Gorilla Grodd and Monsieur Mallah team up as G.A.S.P. (short for Gorillas and Apes Seizing Power) to replace Gotham City's population with gorillas. Gorilla Boss is defeated by B'wana Beast and Vixen (whom he taunts mercilessly because she is not as strong as he).