He soon became friendly with Friedrich Schleiermacher and de Wette, and was associated with them in 1819 in the redaction of the Theologische Zeitschrift. Meanwhile his lectures and publications (among the latter a Grundriss der Neutestamentlichen Hermeneutik, 1816) had brought him into considerable repute, and he was appointed professor extraordinarius in the new University of Bonn in the spring of 1818; in the following autumn he became professor ordinarius. From Bonn, where he had JCW Augusti (1772–1841), JKL Gieseler, and Karl Immanuel Nitzsch for colleagues, he was called in 1827 to Göttingen to succeed KF Staudlin (1761-1826). In that year he helped to found the Theologische Studien und Kritiken, the chief organ of the "mediation" theology (Vermittelungstheologie). At Göttingen he remained, declining all further calls elsewhere, as to Erlangen, Kiel, Halle, Tübingen, Jena and Leipzig, until his death.
Luecke, who was one of the most learned, many-sided and influential of the so-called "mediation" school of evangelical theologians (Vermittelungstheologie), is now chiefly known by his Kommentar über die Schriften d. Evangelisten Johannes (4 vols., 1820–1832). He is an intelligent maintainer of the Johannine authorship of the Fourth Gospel; in connection with this thesis he was one of the first to argue for the early date and non-apostolic authorship of the Apocalypse. His Einleitung in die Offenbarung Johannes was published in 1832. He also published a Synopsis Evangeliorum, jointly with W. M. L. de Wette (1818).