After graduating from Toronto's Sheridan College, where he was classically trained as an animator, Annable ended up at LucasArts. He worked there for ten years, ultimately as a lead animator. In addition, Annable has done illustration and cartoon work for (among others) Chuck Jones, Nickelodeon, and Walt Disney Productions. His self-produced short animated films are also popular among YouTube watchers. Annable was most recently employed as creative director at Telltale Games, and has continued working closely with them.
In February 2013, it was announced that he is co-directing at Laika a 3D stop-motion/CGI animated feature film, titled The Boxtrolls, and scheduled for 2014.