Grand-Popo is a town, arrondissement, and commune in the Mono Department of south-western Benin. The commune covers an area of 289 square kilometres and as of 2002 had a population of 40,335 people.
The Finno-African culture centre Villa Karo has been situated in Grand-Popo since 1999.
It grew around the slave trade, but coastal erosion has now destroyed most of the old town. The town is now a centre for voodoo and home to a Finnish – African cultural centre, Villa Karo. The town's main industry is fishing.
The town inspired the name of the French electronic music duo Grand Popo Football Club, as well as the name of the iPad application creator Grand Popo LLC