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Great Debate may refer to:
- Great Debate (astronomy), an influential debate between the astronomers Harlow Shapley and Heber Curtis
- The Great Debate, also called the Council of Lhasa or the Council of Samye, a decisive debate in Tibetan Buddhism from 792 to 794
- "The Great Debate", a song by Dream Theater from their 2002 album Six Degrees of Inner Turbulence
- Great Debates (international relations)
- The Great Debate (TV series), a VH1 program (2009–present)
- The Great Debate, an influential debate on the future of radiation oncology between leading Dutch professors in medical physics (2013)
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