- Not to be confused with the Great Lakes Football League.
The Great Lakes Football Conference (GLFC) began operations in the 2006 season, with six institutions competing. After the 2011 season the remaining institutions moved into the Great Lakes Valley Conference. A previous incarnation of the conference was disbanded after the 1999 season.
The Great Lakes Valley Conference plans to begin sponsoring football in the fall of 2012. This plan was announced shortly after William Jewell College was admitted to the league, giving the GLVC 16 members and 6 football playing members including William Jewell, Quincy University, University of Indianapolis, and Great Lakes Football Conference members Kentucky Wesleyan College, Missouri University of Science and Technology, and Saint Joseph's College. Later in 2010, McKendree University was admitted into the GLVC as the league's 17th member and 7th football playing member. On October 7, 2010, it was announced that the GLVC had accepted Central State University and Urbana University as associate members in football beginning with the 2012 season.  In effect, this means that the Great Lakes Football Conference will be absorbed by the Great Lakes Valley Conference in 2012.