- "Ukrain" redirects here, For the European country, see Ukraine.
Chelidonium majus (greater celandine; in Europe tetterwort, although in America tetterwort refers to Sanguinaria canadensis) is a herbaceous perennial plant, the only species in the genus Chelidonium. It is native to Europe and western Asia and introduced widely in North America.
The flowers consist of four yellow petals, each about 1 cm long, with two sepals. A double-flowered variety occurs naturally. The flowers appear from late spring to summer in umbelliform cymes of about 4 flowers.
It is considered an aggressive invasive plant in natural areas (both woods and fields). Control is mainly via pulling or spraying the plant before seed dispersal.
The whole plant is toxic in moderate doses as it contains a range of isoquinoline alkaloids but there are numerous therapeutic uses when used at the correct dosage. The main alkaloid present in the herb and root is coptisine. Other alkaloids present include methyl 2'-(7,8-dihydrosanguinarine-8-yl)acetate, allocryptopine, stylopine, protopine, norchelidonine, berberine, chelidonine, sanguinarine, chelerythrine, and 8-hydroxydihydrosanguinarine. Sanguinarine is particularly toxic with anl LD50 of 18 mg per kg body weight (IP in rats). Caffeic acid derivatives are also present.
The effect of the fresh herb is of a mild analgesic, cholagogic, antimicrobial, oncostatic and central nervous system sedative. In in vitro experiments on animal cells celandine is shown to be cytostatic. An immune stimulating effect has also been noted. Some studies show that the alkaloid extraction can have the same effects. The alkaloids are known to cause immobilization in mice after being taken orally or injected. The alkaloids cause limpness and tone reduction of smooth muscle in rabbits. The alkaloids are also noted to stimulate the heart and lungs of frogs, cats and dogs, raising the blood pressure and widening the arteries.
The latex could be employed for cauterizing small open wounds. Early studies of celandine showed that it causes contact dermatitis and eye irritation, particularly from contact with the poisonous red to yellow latex of the stem. This effect has not been observed in animal studies; no inflammation was observed in rabbit eye tests. The latex can leave a non-permanent stain. Stains on skin of the fingers are sometimes reported to cause eye irritation after rubbing the eyes or handling contact lenses. The latex is also known to stain clothes.
The characteristic latex also contains proteolytic enzymes and the phytocystatin chelidostatin, a cysteine protease inhibitor. These co-constituents could explain the topical use of greater celandine against warts and moles.
"Ukrain" (Ukrainian: Україн) is an alternative medicine promoted to treat cancer based on chelidonium. The drug was created in 1978 by the Ukrainian chemist Vasyl Novytskyi. The drug is named in honor of the nation of Ukraine and is produced by an Austrian company Nowicky Pharma. Although the drug was never approved by any regulators, Novytskyi claimed it to be a complete cure for all cancers, radiation-induced diseases and AIDS and was arrested in Vienna for aggravated fraud on September 4, 2012.
The aerial parts and roots of greater celandine are used in herbalism. The above-ground parts are gathered during the flowering season and dried at high temperatures. The root is harvested in autumn between August and October and dried. The fresh rhizome is also used. Celandine has a hot and bitter taste. The latex has a narcotic fragrance. Preparations are made from alcoholic and hot aqueous extractions (tea). The related plant bloodroot has similar chemical composition and uses as greater celandine.
As far back as Pliny the Elder and Dioscorides (1st century CE) this herb has been recognized as a useful detoxifying agent. The root has been chewed to relieve toothache. It was formerly used by gypsies as a foot refresher; modern herbalists use its purgative properties. Juliette de Bairacli Levy, the Jewish-English herbalist, recommended greater celandine for the eyes, diluted with milk, and the latex to be used for getting rid of warts. Chelidonium was a favourite herb of the French herbalist Maurice Mességué.
Chelidonium majus has traditionally been used for treatment of various inflammatory diseases including atopic dermatitis. It is also traditionally used in the treatment of gallstones and dyspepsia.
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- European Medicines Agency. Assessment report on Chelidonium majus L., herba. Date of Publication: 20/01/2012. http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2012/01/WC500120711.pdf
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- The official site about the drug Ukrain
- Allheilmittel gegen Aids und Krebs: Zwei Verhaftungen wegen Betrugs in Wien, Der Standard, 4 Sept. 2012
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- Gabsik Yang, Kyungjin Lee, Mi-Hwa Lee, So-Hyung Kim, In-Hye Ham, Ho-Young Choi, "Inhibitory effects of Chelidonium majus extract on atopic dermatitis-like skin lesions in NC/Nga mice", Journal of Ethnopharmacology, Volume 138, Issue 2, 18 November 2011, Pages 398-403, ISSN 0378-8741, 10.1016/j.jep.2011.09.028. (http://www.sciencedirect.com/science/article/pii/S0378874111006982)
- Mazzanti G., Di Sotto A., Franchitto A., Mammola C.L., Mariani P., Mastrangelo S., Menniti-Ippolito F., Vitalone A. ,"Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment". Journal of Ethnopharmacology. 126 (3) (pp 518-524), 10 Dec 2009.
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- Flora of North America
- Flora Health website
- Blanchan, Neltje (2005). Wild Flowers Worth Knowing. Project Gutenberg Literary Archive Foundation.