As with Alabama's first greatest hits album, Greatest Hits Vol. II includes many of the band's biggest hits of the 1980s, a decade in which they sold millions of albums, had 26 No. 1 singles on Billboard magazine's Hot Country Singles chart and won the "Entertainer of the Decade" honor from the Academy of Country Music. Seven of the album's 10 songs went to No. 1 between 1982–1989; three of them – "Take Me Down", "Dixieland Delight" and "Roll On (Eighteen Wheeler)" – are presented here in their original album-length versions, while the single edits for "The Closer You Get" and "Fallin' Again" are spotlighted.
Two of the album's three new tracks were released as singles, "Then Again" and "Born Country", both of which were top 5 hits on the Billboard Hot Country Singles & Tracks chart.