Meghoo successfully representeded St. Jago High School at the annual Boys Championships in Jamaica. He was a teammate of Bert Cameron as well as Rudolph Briscoe, who competed in the 400 and 800 meters as well. Meghoo's older brother Robert Meghoo competed in the 100 meters but never made it to the Olympics. Another teammate in high school was 10,000 meter Jamaican national record holder Mark "Yifter" Elliott, who now coaches in the USA.
Greg Meghoo is now a United States Citizen, served in the U.S. Army, and is now in the U.S. Air Force Reserves.