Griffithsville is an unincorporated community in eastern Lincoln County, West Virginia, United States. It lies along West Virginia Route 3 southeast of the town of Hamlin, the county seat of Lincoln County. Its elevation is 659 feet (201 m). Although it is unincorporated, it has a post office, with the ZIP code of 25521. It also has a Middle School, two greenhouses, and a Christmas tree farm owned and operated by Larry & Syble Wilkerson and Jeff & Landin Harper. Griffithsville wasn't always small though. In the early 1900s, Griffithsville was a booming oil town. It had boarding houses, several stores, a movie theater, and a Pennzoil pumping station.