Grocott's methenamine silver stain

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A liver biopsy stained using the grocott's methenamine silver stain demonstrating histoplasma (black round balls) in a granuloma.

In pathology, the Grocott-Gomori's (or Gömöri) methenamine silver stain, abbreviated GMS, is a popular staining method in histology.

It is used widely as a screen for fungal organisms. Particularly useful in staining carbohydrates.

It can be used to identify the yeast-like fungus Pneumocystis jiroveci[1] which causes a form of pneumonia called Pneumocystis Pneumonia (PCP) or Pneumocystosis.

The cell walls of these organisms are outlined by the brown to black stain.

See also[edit]

References[edit]

  1. ^ Nassar A, Zapata M, Little JV, Siddiqui MT (November 2006). "Utility of reflex gomori methenamine silver staining for Pneumocystis jirovecii on bronchoalveolar lavage cytologic specimens: A review". Diagn. Cytopathol. 34 (11): 719–23. doi:10.1002/dc.20540. PMID 17041954.