Ground glass hepatocyte
In liver pathology, a ground glass hepatocyte, abbreviated GGH, is a liver parenchymal cell with a flat hazy and uniformly dull appearing cytoplasm on light microscopy. The cytoplasm's granular homogeneous eosinophilic staining is caused by the presence of HBsAg.
The appearance is classically associated with abundant hepatitis B antigen in the endoplasmic reticulum, but may also be drug-induced. In the context of hepatitis B, GGHs are only seen in chronic infections, i.e. they are not seen in acute hepatitis B.
Types of ground glass hepatocytes
Several different types of GGHs are recognized:
- Type I - morphologically consist of GGHs that are scattered singly and have weak Pre-S2 positive immunostaining.
- Type II - morphologically consist of GGHs that are in clusters and have Pre-S2 negative immunostaining.
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