Despite rumours surrounding the song's meaning, lead singer Justin Hawkins has refuted suggestions that the lyrics pertain to pubic lice or sexually transmitted infections: "People have said it's about pubic lice, but that's obviously wrong because pubic lice don't grow on you, do they?" Hawkins has also commented on the song's true meaning: "A sweet lady woman that you will never fully fathom or understand, but you love her so much that after a while it doesn't matter."
The song is featured in the soundtrack to the film School of Rock, despite not actually appearing in the motion picture. The film itself contains another song by the Darkness, "Black Shuck". This change is likely due to the strong language in "Black Shuck"; changing the song on the released soundtrack would avoid an advisory sticker on the release and allow members of the target audience—namely children—to widely purchase the album. It was also featured in the 2004 film Going the Distance.