Growth hormone 2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Growth hormone 2
Protein GH2 PDB 1a22.png
PDB rendering based on 1a22.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GH2 ; GH-V; GHL; GHV; hGH-V
External IDs OMIM139240 HomoloGene128757 GeneCards: GH2 Gene
RNA expression pattern
PBB GE GH1 205840 x at tn.png
PBB GE GH2 211508 s at tn.png
PBB GE GH2 206195 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2689 n/a
Ensembl ENSG00000136487 n/a
UniProt P01242 n/a
RefSeq (mRNA) NM_002059 n/a
RefSeq (protein) NP_002050 n/a
Location (UCSC) Chr 17:
61.96 – 61.96 Mb
PubMed search [1] n/a

Growth hormone variant is a protein that in humans is encoded by the GH2 gene.[1][2]

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.[2]


Further reading[edit]