Gs alpha subunit

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GNAS complex locus
Identifiers
Symbol GNAS
Alt. symbols GNAS1
Entrez 2778
HUGO 4392
OMIM 139320
RefSeq NM_000516
UniProt Q5JWF2
Other data
Locus Chr. 20 q13.2-13.3

The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylate cyclase.

Receptors[edit]

The G protein-coupled receptors that couple to this kind of G-protein include:

Function[edit]

The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs are thus found in function of cAMP-dependent protein kinase.

It provides a step in signal transduction. Amplification of the signal occurs for instance because the receptor activates several Gs. [1] However, each Gs activates only one adenylate cyclase.[1]

See also[edit]

External links[edit]

References[edit]

  1. ^ a b Page 155 in: Purves (2007). Neuroscience, 4th Edition. Sinauer Associates Inc. ISBN 978-0-87893-697-7.