Guanabenz

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Guanabenz
Guanabenz.svg
Guanabenz sf.png
Systematic (IUPAC) name
2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a686003
Pregnancy cat.
Legal status
?
Pharmacokinetic data
Protein binding 90%
Half-life 6 hours
Identifiers
CAS number 5051-62-7
ATC code None
PubChem CID 5702063
DrugBank DB00629
ChemSpider 4642445 YesY
UNII GGD30112WC YesY
KEGG D04375 YesY
ChEMBL CHEMBL420 YesY
Chemical data
Formula C8H8Cl2N4 
Mol. mass 231.081 g/mol
 YesY (what is this?)  (verify)

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 adrenergic receptor that is used as an antihypertensive drug. It is used to treat high blood pressure (hypertension).[1][2]

The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.

Synthesis[edit]

Guanabenz synthesis: J. Yates and E. Haddock, SHELL INT RESEARCH; GB 1019120  (1966).

2,6-dichlorobenzaldehyde + hydrazinylguanidine → Guanaben (Hydrazone formation)

See also[edit]

References[edit]

  1. ^ Walker BR, Hare LE, Deitch MW (1982). "Comparative antihypertensive effects of guanabenz and clonidine". The Journal of International Medical Research 10: 6–14. PMID 7037502. 
  2. ^ Bonham AC, Trapani AJ, Portis LR, Brody MJ (1984). "Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine". Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension 2: S543–6.