Guanosine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Not to be confused with Guanine, Guanidine, or Guanfacine. ‹See Tfd›
Guanosine
Guanosin.svg
Identifiers
CAS number 118-00-3 YesY
PubChem 765
ChemSpider 6544 YesY
UNII 12133JR80S YesY
DrugBank DB02857
KEGG C00387 YesY
MeSH Guanosine
ChEBI CHEBI:16750 YesY
ChEMBL CHEMBL375655 YesY
Jmol-3D images Image 1
Properties
Molecular formula C10H13N5O5
Molar mass 283.241
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP). When guanine is attached by its N9 nitrogen to the C1 carbon of a deoxyribose ring it is known as deoxyguanosine.

The antiviral drug aciclovir, often used in herpes treatment, is structurally similar to guanosine.

Guanosine is required for an RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein.[1]

Guanosine with numbered carbons

References[edit]