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Molecular formula C
10H 13N 5O 5
Molar mass 283.241
Except where noted otherwise, data are given for materials in their
standard state (at 25 °C (77 °F), 100 kPa)
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Guanosine is a purine nucleoside comprising guanine attached to a ribose ( ribofuranose) ring via a β-N 9- glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP). When guanine is attached by its N9 nitrogen to the C1 carbon of a deoxyribose ring it is known as deoxyguanosine.
The antiviral drug
aciclovir, often used in herpes treatment, is structurally similar to guanosine.
Guanosine is required for an
RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein. [1 ]
Guanosine with numbered carbons
References [ edit ]