Guanylate cyclase 2C

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Guanylate cyclase 2C (heat stable enterotoxin receptor)
Identifiers
Symbols GUCY2C ; DIAR6; GUC2C; MECIL; MUCIL; STAR
External IDs OMIM601330 MGI106903 HomoloGene3641 ChEMBL: 1795197 GeneCards: GUCY2C Gene
EC number 4.6.1.2
Orthologs
Species Human Mouse
Entrez 2984 14917
Ensembl ENSG00000070019 ENSMUSG00000042638
UniProt P25092 Q3UWA6
RefSeq (mRNA) NM_004963 NM_001127318
RefSeq (protein) NP_004954 NP_001120790
Location (UCSC) Chr 12:
14.77 – 14.85 Mb
Chr 6:
136.7 – 136.78 Mb
PubMed search [2] [3]

Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.[1][2]

Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.[3] The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.

Functions[edit]

GC-C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea.[4] Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.

Diagnostic application[edit]

Because GC-C is tissue-specific for intestinal epithelium, it can be used for detection of metastatic disease.[citation needed][clarification needed]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: guanylate cyclase 2C (heat stable enterotoxin receptor)". 
  2. ^ Mann EA, Swenson ES, Copeland NG, Gilbert DJ, Jenkins NA, Taguchi T, Testa JR, Giannella RA (June 1996). "Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12". Genomics 34 (2): 265–7. doi:10.1006/geno.1996.0284. PMID 8661067. 
  3. ^ Intestinal Protein May Have Role in ADHD, Other Neurological Disorders. ScienceDaily (Aug. 11, 2011) [1]
  4. ^ Weiglmeier PR, Rösch P, Berkner H (August 2010). "Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C". Toxins 2 (9): 2213–2229. doi:10.3390/toxins2092213. 

Further reading[edit]

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