Guarana (//, from the Portuguese guaraná [ɡwaɾɐˈna]), Paullinia cupana, syn. P. crysan, P. sorbilis) is a climbing plant in the maple family, Sapindaceae, native to the Amazon basin and especially common in Brazil. Guarana features large leaves and clusters of flowers, and is best known for its fruit, which is about the size of a coffee bean. As a dietary supplement, guarana is an effective stimulant: its seeds contain about twice the concentration of caffeine found in coffee beans (about 2–4.5% caffeine in guarana seeds compared to 1–2% for coffee beans).
The guarana fruit's colour ranges from brown to red and contains black seeds which are partly covered by white arils. The colour contrast when the fruit has been split open has been likened to eyeballs; this has formed the basis of a myth.
History and culture
Guarana plays an important role in Tupi and Guaraní Paraguayan culture. According to a myth attributed to the Sateré-Maué tribe, guarana's domestication originated with a deity killing a beloved village child. To console the villagers, a more benevolent god plucked the left eye from the child and planted it in the forest, resulting in the wild variety of guarana. The god then plucked the right eye from the child and planted it in the village, giving rise to domesticated guarana.
The Guaranís would make a tisane by shelling, washing and drying the seeds, followed by pounding them into a fine powder. The powder is kneaded into a dough and then shaped into cylinders. This product is known as guarana bread, which would be grated and then immersed into hot water along with sugar.
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According to the Biological Magnetic Resonance Data Bank, guaranine is defined as only the caffeine chemical in guarana, it is identical to the caffeine chemical derived from other sources, for example coffee, tea, and maté. Guaranine, theine, and mateine are all synonyms for caffeine when the definitions of those words include none of the properties and chemicals of their host plants except the chemical caffeine. Natural sources of caffeine contain widely varying mixtures of xanthine alkaloids other than caffeine, including the cardiac stimulants theophylline and theobromine and other substances such as polyphenols, which can form insoluble complexes with caffeine. The main natural phenols found in guarana are (+)-catechin and (-)-epicatechin.
Brazil, which is the third-largest consumer of soft drinks in the world, produces several soft drink brands from guarana extract. The Portuguese word guaraná is widely used in Brazil as a reference to soft drinks containing guarana extract.
A 2007 human pilot study assessed acute behavioral effects to four doses (37.5 mg, 75 mg, 150 mg and 300 mg) of guarana extract. Memory, alertness and mood were increased by the two lower doses, confirming previous results of cognitive improvement following 75 mg guarana.
Other uses and side effects
Preliminary research has shown guarana may affect how quickly the body perceives itself to be full. One study showed an average 5.1 kg (11.2 lb) weight loss in a group taking a mixture of yerba mate, guarana, and damiana, compared to an average one-pound loss in a placebo group after 45 days. Although inconclusive about specific effects due only to guarana, this study differs from another showing no effect on body weight of a formula containing guarana.
Guarana extract reduced aggregation of rabbit platelets by up to 37 percent below control values and decreased platelet thromboxane formation from arachidonic acid by 78 percent below control values. It is not known if such platelet action has any effect on the risk of heart attack or ischemic stroke.
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