Guddu Barrage is used to control water flow in the River Indus for irrigation and flood control purposes.
It has a discharge capacity of 1.2 million cubic feet per second (34,000 m³/s). It is a gate-controlled weir type barrage with a navigation lock. The barrage has 64 bays, each 60 feet (18 m) wide. The maximum flood level height of Guddu Barrage is 26 feet (8 m). It controls irrigation supplies to 2.9 million acres (12,000 km²) of agricultural land in the Jacobabad, Larkana and Sukkur districts of Sindh province and the Naseerabad district of Balochistan province. It feeds Ghotki Feeder, Begari Feeder, Desert and Pat Feeder canals.