Guelmim-Es Semara (Arabic: كلميم السمارة) is one of the sixteen regions of Morocco. It covers an area of 122,825 km² and has a population of 501,921 (2014 census).
The southern half of Guelmin-Es Semara forms part of the Western Sahara. The regional capital is Guelmim. The region is bordered to the north by Souss-Massa-Drâa and to the west by Laayoune-Boujdour-Sakia El Hamra, with the Algerian province of Tindouf to the east. Its disputed territory in the Western Sahara borders the Mauritanian Tiris Zemmour Region. Guelmin-Es Semara has a coastline on the Atlantic Ocean, with the Spanish Canary Islands lying off it. The Draa River, at 1,100 km the longest in Morocco, flows into the Ocean near Tan-Tan.
The region is made up of the following provinces:
Municipalities by population (2004 census)
- Guelmin, Guelmim Province: 95,599
- Tan-Tan, Tan-Tan Province: 60,560
- Es Semara, Es Smara Province: 33,910
- Tata, Tata Province: 15,192
- Bouizakarne, Guelmim Province: 11,982
- Assa, Assa-Zag Province: 11,667
- Foum Zguid, Tata Province: 9,611
- Zag, Assa-Zag Province: 7,751
- El Ouatia, Tan-Tan Province: 6,294
- Akka, Tata Province: 6,312
- Fam El Hisn, Tata Province: 6,183