The university was founded in 1941, as National Guiyang Normal College (国立贵阳师范学院). After the formation of the People's Republic of China, it was renamed Guiyang Normal College. In 1985, it became Guizhou Normal University. The university was accredited with being a provincial key university in Guizhou in 1996. In 2004, the former Guizhou Vocational Institute of Technology merged into the University.