|— City —|
|• Type||City Council|
|• Mayor||Scott A. Marshall|
|• Total||1.4 sq mi (3.5 km2)|
|• Land||1.4 sq mi (3.5 km2)|
|• Water||0.0 sq mi (0.0 km2)|
|Elevation||548 ft (167 m)|
|• Density||1,079.5/sq mi (416.8/km2)|
|Time zone||Central (CST) (UTC-6)|
|• Summer (DST)||CDT (UTC-5)|
|GNIS feature ID||0493506|
Guthrie is located at .(36.647396, -87.170725)
According to the United States Census Bureau, the city has a total area of 1.4 square miles (3.6 km2), all of it land.
The site that is now Guthrie was settled by the 1840s and may have been called State Line. Guthrie is named for James Guthrie, president of the Louisville and Nashville Railroad when the city was incorporated in 1867.
As of the census of 2000, there were 1,469 people, 593 households, and 377 families residing in the city. The population density was 1,079.5 people per square mile (417.0/km²). There were 657 housing units at an average density of 482.8 per square mile (186.5/km²). The racial makeup of the city was 67.60% White, 29.20% African American, 0.48% Native American, 0.20% Asian, 0.20% Pacific Islander, 1.36% from other races, and 0.95% from two or more races. Hispanic or Latino of any race were 2.59% of the population.
There were 593 households out of which 34.2% had children under the age of 18 living with them, 39.5% were married couples living together, 19.9% had a female householder with no husband present, and 36.3% were non-families. 31.7% of all households were made up of individuals and 13.3% had someone living alone who was 65 years of age or older. The average household size was 2.48 and the average family size was 3.10.
In the city the population was spread out with 28.8% under the age of 18, 9.5% from 18 to 24, 29.1% from 25 to 44, 18.8% from 45 to 64, and 13.8% who were 65 years of age or older. The median age was 34 years. For every 100 females there were 92.3 males. For every 100 females age 18 and over, there were 86.5 males.
The median income for a household in the city was $25,682, and the median income for a family was $31,083. Males had a median income of $27,868 versus $20,240 for females. The per capita income for the city was $13,283. About 23.6% of families and 25.2% of the population were below the poverty line, including 31.5% of those under age 18 and 25.6% of those age 65 or over.
 Guthrie City Renewal Project
The city administration of Guthrie, Kentucky partnered with the University of Kentucky's College of Design to reform the urban plan for the city of Guthrie. The city had become a foible to the state of Kentucky since its decline in the 1970s and later in the 1990s for a racial shooting that made headlines in national newspapers, television networks, and magazines. The level of poverty in the city had risen to levels far above the state and national average causing the city to become segregated from its parent county. In 2006, the city petitioned the University of Kentucky for help in developing a new plan for the future of the community. The College of Design accepted the project, reaffirming its position as a land grant institution with remarks that, "architecture is a humanitarian effort." The first project known as the Guthrie Transportation Museum became the hub project of the renewal effort. In December 2007, Matthew Colin Bailey, along with assistance from the College of Design, created schematic plans to revive the city. The city received multiple grants in amounts of over 1.4 million from the State of Kentucky to begin the restoration of the downtown area and a branding campaign to improve the city's image via District Regionalism. In 2009, the award winning architecture firm of Deleon + Primmer was awarded the final design of the project.
 Notable natives
- Kent Greenfield - American major league baseball player 
- Ed Holland - Cartoonist
- Robert Penn Warren - Pulitzer prize-winning novelist and poet
- "US Gazetteer files: 2010, 2000, and 1990". United States Census Bureau. 2011-02-12. Retrieved 2011-04-23.
- Rennick, Robert M. (1987). "Kentucky Place Names". University Press of Kentucky. p. 127. Retrieved 2013-04-28.
- "Dictionary of Places: Guthrie". Encyclopedia of Kentucky. New York, New York: Somerset Publishers. 1987. ISBN 0-403-09981-1.
- "American FactFinder". United States Census Bureau. Retrieved 2008-01-31.