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H1 histone family, member O, oocyte-specific
Symbols H1FOO ; osH1
External IDs MGI2176207 HomoloGene51377 GeneCards: H1FOO Gene
Species Human Mouse
Entrez 132243 171506
Ensembl ENSG00000178804 ENSMUSG00000042279
UniProt Q8IZA3 Q8VIK3
RefSeq (mRNA) NM_153833 NM_138311
RefSeq (protein) NP_722575 NP_612184
Location (UCSC) Chr 3:
129.26 – 129.27 Mb
Chr 6:
115.94 – 115.95 Mb
PubMed search [1] [2]

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[1][2]


Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[2]

It incorporates into sperm chromatin after fertilisation.[3]


  1. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  2. ^ a b "Entrez Gene: H1 histone family". 
  3. ^ Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.