H2AFB1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
H2A histone family, member B1
Identifiers
Symbols H2AFB1 ; H2A.Bbd
External IDs OMIM300445 MGI3642445 HomoloGene129517 GeneCards: H2AFB1 Gene
Orthologs
Species Human Mouse
Entrez 474382 624153
Ensembl ENSG00000198082 ENSMUSG00000067441
UniProt P0C5Y9 n/a
RefSeq (mRNA) NM_001017990 XM_888672.1
RefSeq (protein) NP_001017990 XP_893765.1
Location (UCSC) Chr HG1497_PATCH:
154.09 – 154.09 Mb
Chr X:
114.13 – 114.13 Mb
PubMed search [1] [2]

Histone H2A-Bbd type 1 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB1 gene (H2A histone family, member B1).[1]

Function[edit]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene.[1]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.