H2AFV

H2A histone family, member V
PDB rendering based on 1f66.
Available structures PDB 1f66
Identifiers
Symbols	H2AFV; FLJ26479; H2AV; MGC10170; MGC10831; MGC1947
External IDs	MGI: 1924855 HomoloGene: 83271 GeneCards: H2AFV Gene
Gene Ontology Molecular function • DNA binding Cellular component • nucleosome • nucleus • chromosome Biological process • nucleosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	94239	77605
Ensembl	ENSG00000105968	ENSMUSG00000041126
UniProt	Q71UI9	Q3THW5
RefSeq (mRNA)	NM_012412.4	XM_126043
RefSeq (protein)	NP_036544.1	XP_126043
Location (UCSC)	Chr 7: 44.87 – 44.89 Mb	Chr 11: 6.33 – 6.34 Mb
PubMed search	[1]	[2]

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcripts have been identified for this gene.

Further reading

• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. PMC 110633. PMID 9566873. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110633. 
• Deng L, de la Fuente C, Fu P et al (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology 277 (2): 278–295. doi:10.1006/viro.2000.0593. PMID 11080476. 
• Deng L, Wang D, de la Fuente C et al (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology 289 (2): 312–326. doi:10.1006/viro.2001.1129. PMID 11689053. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Hillier LW, Fulton RS, Fulton LA et al (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–164. doi:10.1038/nature01782. PMID 12853948. 
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–6561. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291826. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Oh JH, Yang JO, Hahn Y et al (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
• Kimura K, Wakamatsu A, Suzuki Y et al (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Boyne MT, Pesavento JJ, Mizzen CA, Kelleher NL (2006). "Precise characterization of human histones in the H2A gene family by top down mass spectrometry". J. Proteome Res. 5 (2): 248–253. doi:10.1021/pr050269n. PMID 16457589. 
• Kim SC, Sprung R, Chen Y et al (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell 23 (4): 607–618. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.