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ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Symbols AGAP1 ; AGAP-1; CENTG2; GGAP1; cnt-g2
External IDs OMIM608651 MGI2653690 HomoloGene56689 GeneCards: AGAP1 Gene
Species Human Mouse
Entrez 116987 347722
Ensembl ENSG00000157985 ENSMUSG00000055013
UniProt Q9UPQ3 Q8BXK8
RefSeq (mRNA) NM_001037131 NM_001037136
RefSeq (protein) NP_001032208 NP_001032213
Location (UCSC) Chr 2:
236.4 – 237.04 Mb
Chr 1:
89.45 – 89.9 Mb
PubMed search [1] [2]

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an enzyme that in humans is encoded by the AGAP1 gene.[1]

CENTG2 belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin cytoskeleton dynamics (Nie et al., 2002).[supplied by OMIM][1]


HACNS1 is located in an intron of the gene CENTG2 (also known as Human Accelerated Region 2). HACNS1 is hypothesized to be a gene enhancer "that may have contributed to the evolution of the uniquely opposable human thumb, and possibly also modifications in the ankle or foot that allow humans to walk on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human genome, HACNS1 has undergone the most change during the evolution of humans following the split with the ancestors of chimpanzees.[2]


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