HAMP

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Hepcidin antimicrobial peptide

PDB rendering based on 1m4f.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HAMP ; HEPC; HFE2B; LEAP1; PLTR
External IDs OMIM606464 HomoloGene81623 GeneCards: HAMP Gene
RNA expression pattern
PBB GE HAMP 220491 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57817 n/a
Ensembl ENSG00000105697 n/a
UniProt P81172 n/a
RefSeq (mRNA) NM_021175 n/a
RefSeq (protein) NP_066998 n/a
Location (UCSC) Chr 19:
35.77 – 35.78 Mb
n/a
PubMed search [1] n/a

Hepcidin is a protein that in humans is encoded by the HAMP gene.[1][2][3]

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.[3]

See also[edit]

References[edit]

  1. ^ Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K (Nov 2000). "LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity". FEBS Lett 480 (2–3): 147–50. doi:10.1016/S0014-5793(00)01920-7. PMID 11034317. 
  2. ^ Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O (May 2001). "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload". J Biol Chem 276 (11): 7811–9. doi:10.1074/jbc.M008923200. PMID 11113132. 
  3. ^ a b "Entrez Gene: HAMP hepcidin antimicrobial peptide". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.