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Hyaluronan and proteoglycan link protein 2
Symbols HAPLN2 ; BRAL1
External IDs MGI2137300 HomoloGene11045 GeneCards: HAPLN2 Gene
Species Human Mouse
Entrez 60484 73940
Ensembl ENSG00000132702 ENSMUSG00000004894
UniProt Q9GZV7 Q9ESM3
RefSeq (mRNA) NM_021817 NM_022031
RefSeq (protein) NP_068589 NP_071314
Location (UCSC) Chr 1:
156.59 – 156.6 Mb
Chr 3:
88.02 – 88.03 Mb
PubMed search [1] [2]

Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a protein that in humans is encoded by the HAPLN2 gene.[1] HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain.


Bral1 interacts with versican and brevican in nodes of Ranvier. In mice with reduced Bralp1 expression the extracellular matrix at nodes of Ranvier is disrupted and action potential conduction is abnormal.[2]


  1. ^ "Entrez Gene: hyaluronan and proteoglycan link protein 2". 
  2. ^ Bekku, Y.; Vargová, L.; Goto, Y.; Vorísek, I.; Dmytrenko, L.; Narasaki, M.; Ohtsuka, A.; Fässler, R.; Ninomiya, Y.; Syková, E.; Oohashi, T. (2010). "Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS". Journal of Neuroscience 30 (8): 3113–3123. doi:10.1523/JNEUROSCI.5598-09.2010. PMID 20181608.  edit

Further reading[edit]

  • Spicer AP, Joo A, Bowling RA (2003). "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.". J. Biol. Chem. 278 (23): 21083–91. doi:10.1074/jbc.M213100200. PMID 12663660. 
  • Kähler AK, Djurovic S, Rimol LM et al. (2011). "Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.". Biol. Psychiatry 69 (1): 90–6. doi:10.1016/j.biopsych.2010.07.035. PMID 20950796. 
  • Nomoto H, Oohashi T, Hirakawa S et al. (2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.". Acta Med. Okayama 56 (1): 25–9. PMID 11873941. 
  • Martins-de-Souza D, Gattaz WF, Schmitt A et al. (2009). "Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.". J Neural Transm 116 (3): 275–89. doi:10.1007/s00702-008-0156-y. PMID 19034380. 
  • Oohashi T, Hirakawa S, Bekku Y et al. (2002). "Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems.". Mol. Cell. Neurosci. 19 (1): 43–57. doi:10.1006/mcne.2001.1061. PMID 11817897. 
  • Hirakawa S, Oohashi T, Su WD et al. (2000). "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.". Biochem. Biophys. Res. Commun. 276 (3): 982–9. doi:10.1006/bbrc.2000.3583. PMID 11027579. 
  • Sim H, Hu B, Viapiano MS (2009). "Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.". J. Biol. Chem. 284 (39): 26547–56. doi:10.1074/jbc.M109.013185. PMC 2785343. PMID 19633295.