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Not to be confused with Hamilton Anxiety Rating Scale.
Histidyl-tRNA synthetase
Protein HARS PDB 1x59.png
PDB rendering based on 1x59.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HARS ; HRS; USH3B
External IDs OMIM142810 MGI108087 HomoloGene1592 ChEMBL: 4002 GeneCards: HARS Gene
EC number
RNA expression pattern
PBB GE HARS 202042 at tn.png
More reference expression data
Species Human Mouse
Entrez 3035 15115
Ensembl ENSG00000170445 ENSMUSG00000001380
UniProt P12081 Q61035
RefSeq (mRNA) NM_001258040 NM_008214
RefSeq (protein) NP_001244969 NP_032240
Location (UCSC) Chr 5:
140.05 – 140.07 Mb
Chr 18:
36.77 – 36.78 Mb
PubMed search [1] [2]

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.[1][2]


Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins.[3] The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter.[1]

Clinical significance[edit]

The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.[3]


HARS has been shown to interact with EEF1B2[4] and EEF1G.[4]


  1. ^ a b "Entrez Gene: HARS histidyl-tRNA synthetase". 
  2. ^ Wasmuth JJ, Carlock LR (1986). "Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5". Somat. Cell Mol. Genet. 12 (5): 513–7. doi:10.1007/BF01539922. PMID 3464104. 
  3. ^ a b Freist W, Verhey JF, Rühlmann A, Gauss DH, Arnez JG (1999). "Histidyl-tRNA synthetase". Biol. Chem. 380 (6): 623–46. doi:10.1515/BC.1999.079. PMID 10430027. 
  4. ^ a b Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477. 

Further reading[edit]