HAS2

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Hyaluronan synthase 2
Identifiers
Symbols HAS2 ; MGC126241; MGC126242
External IDs OMIM601636 MGI107821 HomoloGene3892 GeneCards: HAS2 Gene
EC number 2.4.1.212
RNA expression pattern
PBB GE HAS2 206432 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3037 15117
Ensembl ENSG00000170961 ENSMUSG00000022367
UniProt Q92819 P70312
RefSeq (mRNA) NM_005328 NM_008216
RefSeq (protein) NP_005319 NP_032242
Location (UCSC) Chr 8:
122.62 – 122.65 Mb
Chr 15:
56.67 – 56.69 Mb
PubMed search [1] [2]

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.[1][2]

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-Transporter[3] into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.[2]

References[edit]

  1. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154. 
  2. ^ a b "Entrez Gene: HAS2 hyaluronan synthase 2". 
  3. ^ Schulz,T.; Schumacher,U.; Prehm,P. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J.Biol.Chem.282,20999-21004

Further reading[edit]