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Hyaluronan synthase 3
Symbol HAS3
External IDs OMIM602428 MGI109599 HomoloGene68461 GeneCards: HAS3 Gene
EC number
Species Human Mouse
Entrez 3038 15118
Ensembl ENSG00000103044 ENSMUSG00000031910
UniProt O00219 O08650
RefSeq (mRNA) NM_001199280 NM_008217
RefSeq (protein) NP_001186209 NP_032243
Location (UCSC) Chr 16:
69.14 – 69.15 Mb
Chr 8:
106.87 – 106.88 Mb
PubMed search [1] [2]

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.[1][2][3]

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.[3]


  1. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154. 
  2. ^ Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017. 
  3. ^ a b "Entrez Gene: HAS3 hyaluronan synthase 3". 

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