HBXIP
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| Hepatitis B virus x interacting protein | |||||||||||||
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 Rendering based on PDB 3MS6. |
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| Identifiers | |||||||||||||
| Symbols | HBXIP; MGC71071; XIP | ||||||||||||
| External IDs | OMIM: 608521 MGI: 1915826 HomoloGene: 4668 GeneCards: HBXIP Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10542 | 68576 | |||||||||||
| Ensembl | ENSG00000134248 | ENSMUSG00000087260 | |||||||||||
| UniProt | O43504 | Q9D1L9 | |||||||||||
| RefSeq (mRNA) | NM_006402 | NM_026774.2 | |||||||||||
| RefSeq (protein) | NP_006393 | NP_081050.2 | |||||||||||
| Location (UCSC) | Chr 1: 110.94 – 110.95 Mb |
Chr 3: 107.08 – 107.09 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.[1][2]
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.[2]
[edit] Interactions
HBXIP has been shown to interact with NCOA6.[3]
[edit] References
- ^ Melegari M, Scaglioni PP, Wands JR (Mar 1998). "Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication". J Virol 72 (3): 1737–43. PMC 109461. PMID 9499022. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109461.
- ^ a b "Entrez Gene: HBXIP hepatitis B virus x interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10542.
- ^ Kong, Hee Jeong; Park Min Jung, Hong SunHwa, Yu Hyun Jung, Lee Young Chul, Choi Young Hyun, Cheong JaeHun (Nov. 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology (United States) 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865.
[edit] Further reading
- Shamay M, Barak O, Doitsh G et al (2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J. Biol. Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
- Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Marusawa H, Matsuzawa S, Welsh K et al (2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression". EMBO J. 22 (11): 2729–40. doi:10.1093/emboj/cdg263. PMC 156760. PMID 12773388. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=156760.
- Kong HJ, Park MJ, Hong S et al (2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.
- Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Lee SH, Park SG, Lim SO, Jung G (2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes". Biochim. Biophys. Acta 1741 (1–2): 75–84. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.
- Lee AT, Ren J, Wong ET et al (2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage". J. Biol. Chem. 280 (39): 33525–35. doi:10.1074/jbc.M506628200. PMID 16055925.
- Stelzl U, Worm U, Lalowski M et al (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Minczuk M, Mroczek S, Pawlak SD, Stepien PP (2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". FEBS J. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273.
- Muroyama R, Kato N, Yoshida H et al (2007). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma". J. Hepatol. 45 (6): 805–12. doi:10.1016/j.jhep.2006.07.025. PMID 17050029.
- Chen J, Siddiqui A (2007). "Hepatitis B Virus X Protein Stimulates the Mitochondrial Translocation of Raf-1 via Oxidative Stress". J. Virol. 81 (12): 6757–60. doi:10.1128/JVI.00172-07. PMC 1900104. PMID 17428866. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1900104.
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