HCN2

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Hyperpolarization activated cyclic nucleotide-gated potassium channel 2

PDB rendering based on 1q3e.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HCN2 ; BCNG-2; BCNG2; HAC-1
External IDs OMIM602781 MGI1298210 HomoloGene31022 IUPHAR: HCN2 ChEMBL: 1795172 GeneCards: HCN2 Gene
RNA expression pattern
PBB GE HCN2 207592 s at tn.png
PBB GE HCN2 214893 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 610 15166
Ensembl ENSG00000099822 ENSMUSG00000020331
UniProt Q9UL51 O88703
RefSeq (mRNA) NM_001194 NM_008226
RefSeq (protein) NP_001185 NP_032252
Location (UCSC) Chr 19:
0.59 – 0.62 Mb
Chr 10:
79.72 – 79.74 Mb
PubMed search [1] [2]

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.[1][2][3][4]


Interactions[edit]

HCN2 has been shown to interact with HCN1[5][6] and HCN4.[5]

Function[edit]

The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.[7]

See also[edit]

References[edit]

  1. ^ Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc Natl Acad Sci U S A 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696. 
  2. ^ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217. 
  3. ^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. 
  4. ^ "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2". 
  5. ^ a b Much, Barbara; Wahl-Schott Christian, Zong Xiangang, Schneider Angela, Baumann Ludwig, Moosmang Sven, Ludwig Andreas, Biel Martin (Oct 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. (United States) 278 (44): 43781–6. doi:10.1074/jbc.M306958200. ISSN 0021-9258. PMID 12928435. 
  6. ^ Proenza, Catherine; Tran Neil, Angoli Damiano, Zahynacz Kristin, Balcar Petr, Accili Eric A (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". J. Biol. Chem. (United States) 277 (33): 29634–42. doi:10.1074/jbc.M200504200. ISSN 0021-9258. PMID 12034718. 
  7. ^ "Gene find may lead to pills that kill chronic pain". The Times Of India. 10 September 2011. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.