HDAC1

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Histone deacetylase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HDAC1 ; GON-10; HD1; RPD3; RPD3L1
External IDs OMIM601241 MGI108086 HomoloGene68426 ChEMBL: 325 GeneCards: HDAC1 Gene
EC number 3.5.1.98
RNA expression pattern
PBB GE HDAC1 201209 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3065 433759
Ensembl ENSG00000116478 ENSMUSG00000028800
UniProt Q13547 O09106
RefSeq (mRNA) NM_004964 NM_008228
RefSeq (protein) NP_004955 NP_032254
Location (UCSC) Chr 1:
32.76 – 32.8 Mb
Chr 4:
129.52 – 129.54 Mb
PubMed search [1] [2]

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.[1]

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[2]

Model organisms[edit]

Model organisms have been used in the study of HDAC1 function. A conditional knockout mouse line, called Hdac1tm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out and two phenotypes were reported. A reduced number of homozygous mutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice, and no significant abnormalities were observed in these animals.[5]

See also[edit]

Interactions[edit]

HDAC1 has been shown to interact with RAD9A,[13] DNMT3L,[14][15] MTA1,[16][17] FKBP3,[18] CDC20,[19] CDH1,[19] Host cell factor C1,[20] BUB3,[19] Nuclear receptor co-repressor 2,[21][22] IKZF1,[23][24] Prohibitin,[25][26] EVI1,[27][28] DDX5,[29] DNMT3A,[30] Mothers against decapentaplegic homolog 2,[31] Histone deacetylase 2,[16][21][32][33][34][35][36][37][38][39][40][41][42] MIER1,[43] SIN3A,[16][38][39][40][44][45][46][47][48][49][50][51][52][53] Death-associated protein 6,[54] Androgen receptor,[55] HMG20B,[32] HUS1,[13] IFRD1,[56] MLL,[57] ING1,[53][58] MyoD,[59][60] GATA1,[61] SPEN,[62] Mad1,[19] Promyelocytic leukemia protein,[63][64] CHD3,[39][53] Homeobox protein TGIF1,[65][66] Retinoblastoma-like protein 2,[67][68] Retinoblastoma-like protein 1,[67][69] CHD4,[16][39][47] RCOR1,[32][49] RBBP7,[16][38][41][70] RFC1,[71] Retinoblastoma protein,[26][59][67][69][72][73][74] RBBP4,[16][38][40][41][44][47][49][50][70][75][76] EED,[42] PHF21A,[32][77] SIN3B,[23][38] RELA,[37][78][79] NFKB1,[79] BUB1B,[19] Mdm2,[80] SATB1,[51] HSPA4,[35] SUV39H1,[81] BUB1,[19] Methyl-CpG-binding domain protein 2,[38][70][82] Zinc finger and BTB domain-containing protein 16,[83][84][85] DDX17,[29] BCL6,[84][86] SUDS3,[45][87] SAP30,[38][53][88][89][90][91] Sp1 transcription factor,[50][92][93][94] MTA2,[16][38][49][51] PCNA,[95] CBFA2T3,[96][97] TOP2B,[98][99] MBD3,[38][100][101] CTBP1,[65][102][103] TOP2A,[98][99] EZH2,[42]BTG2,[104] and COUP-TFII.[105]

References[edit]

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