HDAC11

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Histone deacetylase 11
Identifiers
Symbols HDAC11 ; HD11
External IDs OMIM607226 MGI2385252 HomoloGene11743 IUPHAR: 2615 ChEMBL: 3310 GeneCards: HDAC11 Gene
EC number 3.5.1.98
RNA expression pattern
PBB GE HDAC11 219847 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79885 232232
Ensembl ENSG00000163517 ENSMUSG00000034245
UniProt Q96DB2 Q91WA3
RefSeq (mRNA) NM_001136041 NM_144919
RefSeq (protein) NP_001129513 NP_659168
Location (UCSC) Chr 3:
13.52 – 13.55 Mb
Chr 6:
91.16 – 91.17 Mb
PubMed search [1] [2]

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice.[1][2]

It is the only Class IV HDAC. (Class IV have characteristics of both class I and class II HDAC.) It was first described in 2002.

Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.[supplied by OMIM][2]

Interactions[edit]

HDAC11 has been shown to interact with HDAC6.[1]

Functions[edit]

HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells.

HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.

See also[edit]

References[edit]

  1. ^ a b Gao L, Cueto MA, Asselbergs F, Atadja P (Jul 2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family". J Biol Chem 277 (28): 25748–55. doi:10.1074/jbc.M111871200. PMID 11948178. 
  2. ^ a b "Entrez Gene: HDAC11 histone deacetylase 11". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.