Histone deacetylase 2

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Histone deacetylase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HDAC2 ; HD2; RPD3; YAF1
External IDs OMIM605164 MGI1097691 HomoloGene68187 ChEMBL: 1937 GeneCards: HDAC2 Gene
EC number
RNA expression pattern
PBB GE HDAC2 201833 at tn.png
More reference expression data
Species Human Mouse
Entrez 3066 15182
Ensembl ENSG00000196591 ENSMUSG00000019777
UniProt Q92769 P70288
RefSeq (mRNA) NM_001527 NM_008229
RefSeq (protein) NP_001518 NP_032255
Location (UCSC) Chr 6:
114.25 – 114.33 Mb
Chr 10:
36.97 – 37 Mb
PubMed search [1] [2]

Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene.[1]

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.[2]


Histone deacetylase 2 has been shown to interact with:

See also[edit]


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Further reading[edit]

External links[edit]