Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
^Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem.275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID10748098.
^Koipally J, Georgopoulos K (June 2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression". J. Biol. Chem.277 (26): 23143–9. doi:10.1074/jbc.M202079200. PMID11959865.
Marks PA, Richon VM, Rifkind RA (2000). "Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells.". J. Natl. Cancer Inst.92 (15): 1210–6. doi:10.1093/jnci/92.15.1210. PMID10922406.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res.5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID9872452.
Youn HD, Grozinger CM, Liu JO (2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4.". J. Biol. Chem.275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID10825153.
Zhang CL, McKinsey TA, Lu JR, Olson EN (2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.". J. Biol. Chem.276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID11022042.
Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.". J. Biol. Chem.276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID11466315.
Koipally J, Georgopoulos K (2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression.". J. Biol. Chem.277 (26): 23143–9. doi:10.1074/jbc.M202079200. PMID11959865.
Mahlknecht U, Schnittger S, Will J, Cicek N, Hoelzer D (2002). "Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9).". Biochem. Biophys. Res. Commun.293 (1): 182–91. doi:10.1016/S0006-291X(02)00193-6. PMID12054582.