HEAT repeat domain

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HEAT repeat
PDB 1b3u EBI.jpg
Structure of the protein phosphatase 2A PR65/A subunit revealing the conformation of its 15 tandemly repeated HEAT motifs.[1]
Identifiers
Symbol HEAT
Pfam PF02985
InterPro IPR000357
PROSITE PDOC50077
SCOP 1b3u
SUPERFAMILY 1b3u

The HEAT repeat domain is a solenoid protein domain found in a number of cytoplasmic proteins including the four that the give rise to the acronym HEAT (Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1).[2] HEAT repeats form a rod-like helical structures which are involved in intracellular transport.

References[edit]

  1. ^ Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (January 1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell 96 (1): 99–110. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501. 
  2. ^ Andrade MA, Bork P (October 1995). "HEAT repeats in the Huntington's disease protein". Nat. Genet. 11 (2): 115–6. doi:10.1038/ng1095-115. PMID 7550332. 

External links[edit]