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Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Protein HERPUD1 PDB 1wgd.png
PDB rendering based on 1wgd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HERPUD1 ; HERP; Mif1; SUP
External IDs OMIM608070 MGI1927406 HomoloGene40973 GeneCards: HERPUD1 Gene
RNA expression pattern
PBB GE HERPUD1 217168 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9709 64209
Ensembl ENSG00000051108 ENSMUSG00000031770
UniProt Q15011 Q9JJK5
RefSeq (mRNA) NM_001010989 NM_022331
RefSeq (protein) NP_001010989 NP_071726
Location (UCSC) Chr 16:
56.97 – 56.98 Mb
Chr 8:
94.39 – 94.4 Mb
PubMed search [1] [2]

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein is a protein that in humans is encoded by the HERPUD1 gene.[1][2][3]

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.[3]


HERPUD1 has been shown to interact with UBQLN1[4] and UBQLN2.[3]


  1. ^ Kokame K, Agarwala KL, Kato H, Miyata T (Nov 2000). "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress". J Biol Chem 275 (42): 32846–53. doi:10.1074/jbc.M002063200. PMID 10922362. 
  2. ^ van Laar T, Schouten T, Hoogervorst E, van Eck M, van der Eb AJ, Terleth C (Apr 2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway". FEBS Lett 469 (1): 123–31. doi:10.1016/S0014-5793(00)01253-9. PMID 10708769. 
  3. ^ a b "Entrez Gene: HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1". 
  4. ^ Kim, Tae-Yeon; Kim Eunmin; Yoon Sungjoo Kim; Yoon Jong-Bok (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochem. Biophys. Res. Commun. (United States) 369 (2): 741–6. doi:10.1016/j.bbrc.2008.02.086. PMID 18307982. 

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