HGS (gene)

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Hepatocyte growth factor-regulated tyrosine kinase substrate
PDB 2d3g EBI.jpg
Rendering of HGS from PDB 2D3G
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HGS ; HRS
External IDs OMIM604375 MGI104681 HomoloGene37954 GeneCards: HGS Gene
RNA expression pattern
PBB GE HGS 210428 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9146 15239
Ensembl ENSG00000185359 ENSMUSG00000025793
UniProt O14964 Q99LI8
RefSeq (mRNA) NM_004712 NM_001159328
RefSeq (protein) NP_004703 NP_001152800
Location (UCSC) Chr 17:
79.65 – 79.67 Mb
Chr 11:
120.47 – 120.48 Mb
PubMed search [1] [2]

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.[1][2][3]


HGS (gene) has been shown to interact with:


  1. ^ a b Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H et al. (January 1998). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". J. Biol. Chem. 272 (52): 32785–91. doi:10.1074/jbc.272.52.32785. PMID 9407053.  Check date values in: |year= / |date= mismatch (help)
  2. ^ Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene 213 (1-2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564. 
  3. ^ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate". 
  4. ^ Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. PMC 125612. PMID 11532964. 
  5. ^ Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". J. Neurosci. 22 (15): 6415–25. PMID 12151521. 
  6. ^ a b c Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14): 12513–21. doi:10.1074/jbc.M210843200. PMID 12551915. 
  7. ^ Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. doi:10.1074/jbc.275.20.15271. PMID 10809762. 
  8. ^ Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y et al. (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell. Sci. 121 (Pt 10): 1727–38. doi:10.1242/jcs.024455. PMID 18445679. 
  9. ^ Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. doi:10.1093/hmg/10.8.825. PMID 11285248. 
  10. ^ Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. doi:10.1093/hmg/9.11.1567. PMID 10861283. 
  11. ^ a b c Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  12. ^ Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7626–31. doi:10.1073/pnas.0932599100. PMC 164637. PMID 12802020. 

Further reading[edit]