HGS (gene)

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Hepatocyte growth factor-regulated tyrosine kinase substrate
PDB 2d3g EBI.jpg
Rendering of HGS from PDB 2D3G
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HGS ; HRS
External IDs OMIM604375 MGI104681 HomoloGene37954 GeneCards: HGS Gene
RNA expression pattern
PBB GE HGS 210428 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9146 15239
Ensembl ENSG00000185359 ENSMUSG00000025793
UniProt O14964 Q99LI8
RefSeq (mRNA) NM_004712 NM_001159328
RefSeq (protein) NP_004703 NP_001152800
Location (UCSC) Chr 17:
79.65 – 79.67 Mb
Chr 11:
120.47 – 120.48 Mb
PubMed search [1] [2]

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.[1][2][3]


Interactions[edit]

HGS (gene) has been shown to interact with TSG101,[4][5] STAM2,[4][6] Merlin,[7][8] DLG4,[9] IL2RB,[10] EPS15,[6][11] CLTC[12] and Signal transducing adaptor molecule.[1][4][6]

References[edit]

  1. ^ a b Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K (January 1998). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". J Biol Chem 272 (52): 32785–91. doi:10.1074/jbc.272.52.32785. PMID 9407053. 
  2. ^ Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene 213 (1–2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564. 
  3. ^ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate". 
  4. ^ a b c Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Lu, Quan; Hope Lila Weiqiao; Brasch Michael; Reinhard Christoph; Cohen Stanley N (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (13): 7626–31. doi:10.1073/pnas.0932599100. ISSN 0027-8424. PMC 164637. PMID 12802020. 
  6. ^ a b c Bache, Kristi G; Raiborg Camilla; Mehlum Anja; Stenmark Harald (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. (United States) 278 (14): 12513–21. doi:10.1074/jbc.M210843200. ISSN 0021-9258. PMID 12551915. 
  7. ^ Gutmann, D H; Haipek C A; Burke S P; Sun C X; Scoles D R; Pulst S M (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. (England) 10 (8): 825–34. doi:10.1093/hmg/10.8.825. ISSN 0964-6906. PMID 11285248. 
  8. ^ Scoles, D R; Huynh D P; Chen M S; Burke S P; Gutmann D H; Pulst S M (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. (ENGLAND) 9 (11): 1567–74. doi:10.1093/hmg/9.11.1567. ISSN 0964-6906. PMID 10861283. 
  9. ^ Chetkovich, Dane M; Bunn Robert C; Kuo Sheng-Han; Kawasaki Yoshimi; Kohwi Minoree; Bredt David S (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". J. Neurosci. (United States) 22 (15): 6415–25. PMID 12151521. 
  10. ^ Yamashita, Yuki; Kojima Katsuhiko; Tsukahara Tomonori; Agawa Hideyuki; Yamada Koichiro; Amano Yuji; Kurotori Naoki; Tanaka Nobuyuki; Sugamura Kazuo; Takeshita Toshikazu (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell. Sci. (England) 121 (Pt 10): 1727–38. doi:10.1242/jcs.024455. ISSN 0021-9533. PMID 18445679. 
  11. ^ Bean, A J; Davanger S; Chou M F; Gerhardt B; Tsujimoto S; Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. (UNITED STATES) 275 (20): 15271–8. doi:10.1074/jbc.275.20.15271. ISSN 0021-9258. PMID 10809762. 
  12. ^ Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes". EMBO J. (England) 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964. 

Further reading[edit]