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Hedgehog interacting protein
Protein HHIP PDB 2WFT.png
Rendering based on PDB 2WFT.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HHIP ; HIP
External IDs OMIM606178 MGI1341847 HomoloGene32469 GeneCards: HHIP Gene
RNA expression pattern
PBB GE HHIP gnf1h05971 at tn.png
PBB GE HHIP gnf1h05972 at tn.png
More reference expression data
Species Human Mouse
Entrez 64399 15245
Ensembl ENSG00000164161 ENSMUSG00000064325
UniProt Q96QV1 Q7TN16
RefSeq (mRNA) NM_022475 NM_020259
RefSeq (protein) NP_071920 NP_064655
Location (UCSC) Chr 4:
145.57 – 145.67 Mb
Chr 8:
79.97 – 80.06 Mb
PubMed search [1] [2]

Hedgehog-interacting protein is a protein that in humans is encoded by the HHIP gene.[1][2][3]

This gene encodes a protein similar to the mouse hedgehog-interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.[3]


  1. ^ Bak M, Hansen C, Friis Henriksen K, Tommerup N (Jul 2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". Cytogenet Cell Genet 92 (3–4): 300–3. doi:10.1159/000056918. PMID 11435703. 
  2. ^ Ingham PW, McMahon AP (Dec 2001). "Hedgehog signaling in animal development: paradigms and principles". Genes Dev 15 (23): 3059–87. doi:10.1101/gad.938601. PMID 11731473. 
  3. ^ a b "Entrez Gene: HHIP hedgehog interacting protein". 

Further reading[edit]