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Ubiquitin-conjugating enzyme E2K
Protein HIP2 PDB 1yla.png
PDB rendering based on 1yla.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2K ; E2-25K; HIP2; HYPG; LIG; UBC1
External IDs OMIM602846 MGI1858216 HomoloGene3903 GeneCards: UBE2K Gene
EC number
RNA expression pattern
PBB GE HIP2 202346 at tn.png
PBB GE HIP2 202347 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3093 53323
Ensembl ENSG00000078140 ENSMUSG00000029203
UniProt P61086 P61087
RefSeq (mRNA) NM_001111112 NM_016786
RefSeq (protein) NP_001104582 NP_058066
Location (UCSC) Chr 4:
39.7 – 39.78 Mb
Chr 5:
65.54 – 65.6 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.[1][2][3]

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.[3]


HIP2 has been shown to interact with Huntingtin[1][4] and RNF2.[5]


  1. ^ a b Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625. 
  2. ^ Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885. 
  3. ^ a b "Entrez Gene: HIP2 huntingtin interacting protein 2". 
  4. ^ Faber, P W; Barnes G T; Srinidhi J; Chen J; Gusella J F; MacDonald M E (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. (ENGLAND) 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. ISSN 0964-6906. PMID 9700202. 
  5. ^ Lee, S J; Choi J Y; Sung Y M; Park H; Rhim H; Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. (Netherlands) 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. ISSN 0014-5793. PMID 11513855. 

Further reading[edit]