Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1gene.
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
Ishikawa K, Nagase T, Suyama M et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res.5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID9734811.
Kim YH, Choi CY, Lee SJ et al. (1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J. Biol. Chem.273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID9748262.
Li X, Zhang R, Luo D et al. (2005). "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation". J. Biol. Chem.280 (15): 15061–70. doi:10.1074/jbc.M414262200. PMID15701637.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.