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Homeodomain interacting protein kinase 1
Symbols HIPK1 ; Myak; Nbak2
External IDs OMIM608003 MGI1314873 HomoloGene56483 IUPHAR: 2033 ChEMBL: 5427 GeneCards: HIPK1 Gene
EC number
RNA expression pattern
PBB GE HIPK1 212291 at tn.png
PBB GE HIPK1 212293 at tn.png
More reference expression data
Species Human Mouse
Entrez 204851 15257
Ensembl ENSG00000163349 ENSMUSG00000008730
UniProt Q86Z02 O88904
RefSeq (mRNA) NM_152696 NM_001301304
RefSeq (protein) NP_689909 NP_001288233
Location (UCSC) Chr 1:
114.47 – 114.52 Mb
Chr 3:
103.74 – 103.79 Mb
PubMed search [1] [2]

Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1 gene.[1]

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.[1]


HIPK1 has been shown to interact with P53.[2]


  1. ^ a b "Entrez Gene: HIPK1 homeodomain interacting protein kinase 1". 
  2. ^ Kondo, Seiji; Lu Ying, Debbas Michael, Lin Athena W, Sarosi Ildiko, Itie Annick, Wakeham Andrew, Tuan JoAnn, Saris Chris, Elliott Gary, Ma Weili, Benchimol Samuel, Lowe Scott W, Mak Tak Wah, Thukral Sushil K (Apr 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (9): 5431–6. doi:10.1073/pnas.0530308100. ISSN 0027-8424. PMC 154362. PMID 12702766. 

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