HIPK2

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Homeodomain interacting protein kinase 2
Identifiers
Symbols HIPK2 ; PRO0593
External IDs OMIM606868 HomoloGene68766 ChEMBL: 4576 GeneCards: HIPK2 Gene
EC number 2.7.11.1
Orthologs
Species Human Mouse
Entrez 28996 15258
Ensembl ENSG00000064393 ENSMUSG00000061436
UniProt Q9H2X6 Q9QZR5
RefSeq (mRNA) NM_001113239 NM_001136065
RefSeq (protein) NP_001106710 NP_001129537
Location (UCSC) Chr 7:
139.25 – 139.48 Mb
Chr 6:
38.69 – 38.88 Mb
PubMed search [1] [2]

Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.[1]

HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.[supplied by OMIM][2]

Interactions[edit]

HIPK2 has been shown to interact with SKI protein,[3] Death associated protein 6,[4] P53,[5][6][7] CREB binding protein,[6] Mothers against decapentaplegic homolog 1,[3] TP53INP1[8] and RANBP9.[9]

References[edit]

  1. ^ Wang Y, Hofmann TG, Runkel L, Haaf T, Schaller H, Debatin K, Hug H (Mar 2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2". Biochim Biophys Acta 1518 (1–2): 168–72. doi:10.1016/S0167-4781(00)00308-0. PMID 11267674. 
  2. ^ "Entrez Gene: HIPK2 homeodomain interacting protein kinase 2". 
  3. ^ a b Harada, Jun; Kokura Kenji, Kanei-Ishii Chie, Nomura Teruaki, Khan Md Matiullah, Kim Yongsok, Ishii Shunsuke (Oct 2003). "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation". J. Biol. Chem. (United States) 278 (40): 38998–9005. doi:10.1074/jbc.M307112200. ISSN 0021-9258. PMID 12874272. 
  4. ^ Hofmann, Thomas G; Stollberg Nicole; Schmitz M Lienhard; Will Hans (Dec 2003). "HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells". Cancer Res. (United States) 63 (23): 8271–7. ISSN 0008-5472. PMID 14678985. 
  5. ^ Wang Y, Debatin KM, Hug H (Aug 2001). "HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels". BMC Mol Biol. 2: 8. doi:10.1186/1471-2199-2-8. PMC 48146. PMID 11532197. 
  6. ^ a b Hofmann, Thomas G; Möller Andreas; Sirma Hüaeyin; Zentgraf Hanswalter; Taya Yoichi; Dröge Wulf; Will Hans; Schmitz M Lienhard (Jan 2002). "Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2". Nat. Cell Biol. (England) 4 (1): 1–10. doi:10.1038/ncb715. ISSN 1465-7392. PMID 11740489. 
  7. ^ Kim, Eun-Joo; Park Jong-Sup; Um Soo-Jong (Aug 2002). "Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo". J. Biol. Chem. (United States) 277 (35): 32020–8. doi:10.1074/jbc.M200153200. ISSN 0021-9258. PMID 11925430. 
  8. ^ Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. (United States) 278 (39): 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404. 
  9. ^ Wang, Ying; Marion Schneider E; Li Xin; Duttenhöfer Irina; Debatin Klaus; Hug Hubert (Sep 2002). "HIPK2 associates with RanBPM". Biochem. Biophys. Res. Commun. (United States) 297 (1): 148–53. doi:10.1016/S0006-291X(02)02020-X. ISSN 0006-291X. PMID 12220523. 

Further reading[edit]