HIST1H1A

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Histone cluster 1, H1a
Identifiers
Symbols HIST1H1A ; H1.1; H1A; H1F1; HIST1
External IDs OMIM142709 MGI1931523 HomoloGene68460 GeneCards: HIST1H1A Gene
RNA expression pattern
PBB GE HIST1H1A 208484 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3024 80838
Ensembl ENSG00000124610 ENSMUSG00000049539
UniProt Q02539 P43275
RefSeq (mRNA) NM_005325 NM_030609
RefSeq (protein) NP_005316 NP_085112
Location (UCSC) Chr 6:
26.02 – 26.02 Mb
Chr 13:
23.76 – 23.76 Mb
PubMed search [1] [2]

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.[1][2][3]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Eick S, Nicolai M, Mumberg D, Doenecke D (Sep 1989). "Human H1 histones: conserved and varied sequence elements in two H1 subtype genes". Eur J Cell Biol 49 (1): 110–5. PMID 2759094. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H1A histone cluster 1, H1a". 

Further reading[edit]