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Histone cluster 1, H1b
Protein HIST1H1B PDB 1ghc.png
PDB rendering based on 1ghc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H1B ; H1; H1.5; H1B; H1F5; H1s-3
External IDs OMIM142711 MGI1861461 HomoloGene136789 GeneCards: HIST1H1B Gene
RNA expression pattern
PBB GE HIST1H1B 214534 at tn.png
More reference expression data
Species Human Mouse
Entrez 3009 56702
Ensembl ENSG00000184357 ENSMUSG00000058773
UniProt P16401 P43276
RefSeq (mRNA) NM_005322 NM_020034
RefSeq (protein) NP_005313 NP_064418
Location (UCSC) Chr 6:
27.83 – 27.84 Mb
Chr 13:
21.78 – 21.78 Mb
PubMed search [1] [2]

Histone H1.5 is a protein that in humans is encoded by the HIST1H1B gene.[1][2][3][4]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[4]


  1. ^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620. 
  2. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ a b "Entrez Gene: HIST1H1B histone cluster 1, H1b". 

Further reading[edit]