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Histone cluster 1, H1c
Symbols HIST1H1C ; H1.2; H1C; H1F2; H1s-1
External IDs OMIM142710 MGI1931526 HomoloGene68455 GeneCards: HIST1H1C Gene
RNA expression pattern
PBB GE HIST1H1C 209398 at tn.png
More reference expression data
Species Human Mouse
Entrez 3006 50708
Ensembl ENSG00000187837 ENSMUSG00000036181
UniProt P16403 P15864
RefSeq (mRNA) NM_005319 NM_015786
RefSeq (protein) NP_005310 NP_056601
Location (UCSC) Chr 6:
26.06 – 26.06 Mb
Chr 13:
23.74 – 23.74 Mb
PubMed search [1] [2]

Histone H1.2 is a protein that in humans is encoded by the HIST1H1C gene.[1][2][3]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

Apart from its roles in the nucleus, histone H1.2 also participates in apoptosis. In response to apoptotic stimuli, mainly DNA damage, it is translocated from the nucleus to the cytosol. There, it activates Bak, a pro-apoptotic protein bound to the mithochondria outer membrane (MOM). Activation of Bak causes the perforation of the mitochondria, a process known as MOMP (mitochondria outer membrane permeabilization) which promotes apoptosis. Histone H1.2 also forms a complex with the apoptosome, possibly regulating its formation.


  1. ^ Eick S, Nicolai M, Mumberg D, Doenecke D (Sep 1989). "Human H1 histones: conserved and varied sequence elements in two H1 subtype genes". Eur J Cell Biol 49 (1): 110–5. PMID 2759094. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H1C histone cluster 1, H1c". 

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