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Histone cluster 1, H1d
Symbols HIST1H1D ; H1.3; H1D; H1F3; H1s-2
External IDs OMIM142210 MGI107502 HomoloGene68456 GeneCards: HIST1H1D Gene
RNA expression pattern
PBB GE HIST1H1D 214537 at tn.png
More reference expression data
Species Human Mouse
Entrez 3007 14957
Ensembl ENSG00000124575 ENSMUSG00000052565
UniProt P16402 P43277
RefSeq (mRNA) NM_005320 NM_145713
RefSeq (protein) NP_005311 NP_663759
Location (UCSC) Chr 6:
26.23 – 26.24 Mb
Chr 13:
23.56 – 23.56 Mb
PubMed search [1] [2]

Histone H1.3 is a protein that in humans is encoded by the HIST1H1D gene.[1][2][3]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]


  1. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H1D histone cluster 1, H1d". 

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